Cristina Palacios, Luz Maria De-Regil, Lia K. Lombardo, and Juan Pablo Peña-Rosas.

Published: February 11, 2016

Overview

The present study updates a previous meta-analysis on the effects of oral vitamin D supplementation (alone or in combination with other vitamins and minerals) during pregnancy on maternal 25(OH)D levels and risk of developing adverse gestational outcomes such as pre-eclampsia, gestational diabetes, preterm birth, impaired glucose tolerance, caesarean section, and gestational hypertension.
Fifteen randomized and quasi-randomized trials were included in the review.

Supplementing pregnant women with vitamin D led to increased levels of 25(OH)D at term compared to placebo/control but results were inconsistent. Vitamin D supplementation, with or without calcium, may be related to lower risk of preeclampsia but more studies are needed to confirm this relationship.

Publication

The Journal of Steroid Biochemistry and Molecular Biology

https://www.ncbi.nlm.nih.gov/pubmed/26877200

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